Cdkn1b^tm1Ako
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm1Ako
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 1, Andrew Koff
• MGI ID: MGI:1888808
• Synonyms: Cdkn1b^tm1Kiyo, P27-, p27^D51, p27delta, p27/Kip1^-, p27^{Kip1 -}, p27^Kip1
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm1Ako page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33401
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into the first coding exon of the Cdkn1b gene. Allele produces an N-terminal partial protein product which authors refer to as delta51. (J:33401)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn1b^tm1Ako

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:33401 Kiyokawa H, et al., Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell. 1996 May 31;85(5):721-32
• All: 76 reference(s)