Fli1^tm1Adh
Targeted Allele Detail

Summary

• Symbol: Fli1^tm1Adh
• Name: Friend leukemia integration 1; targeted mutation 1, Adam Hart
• MGI ID: MGI:1888942
• Synonyms: Fli-1^-, Fli-1^LZ, FliresZ, FliresZ-(Fli-1^LZ)
• Gene: Fli1 Location: Chr9:32333500-32454157 bp, - strand Genetic Position: Chr9, 17.74 cM
• Alliance: Fli1^tm1Adh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64178
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the DNA binding (ETS) domain in exon 9 were replaced with an IRES-lacZ and puromycin resistance cassette. Western blot analysis on extracts derived from E9.5 homozygous embryos confirmed that no detectable protein is expressed from this allele. (J:64178)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	69 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fli1 Mutation: 26 strains or lines available

References

• Original: J:64178 Hart A, et al., Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity. 2000 Aug;13(2):167-77
• All: 2 reference(s)