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E2f4tm1Jrn
Targeted Allele Detail
Summary
Symbol: E2f4tm1Jrn
Name: E2F transcription factor 4; targeted mutation 1, Joseph R Nevins
MGI ID: MGI:1888951
Synonyms: E2F4-
Gene: E2f4  Location: Chr8:106024295-106032002 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance: E2f4tm1Jrn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64192
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe null allele was generated by replacing the first three exons of the wild-type locus with a PGK-neo cassette. (J:64192)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any E2f4 Mutation:  21 strains or lines available
References
Original:  J:64192 Rempel RE, et al., Loss of E2F4 activity leads to abnormal development of multiple cellular lineages. Mol Cell. 2000 Aug;6(2):293-306
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory