E2f4^tm1Lees
Targeted Allele Detail

Summary

• Symbol: E2f4^tm1Lees
• Name: E2F transcription factor 4; targeted mutation 1, Jacqueline A Lees
• MGI ID: MGI:1888952
• Synonyms: E2f4^-
• Gene: E2f4 Location: Chr8:106024295-106032002 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: E2f4^tm1Lees page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64193
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was rendered inactive by the introduction of termination codons in all three open-reading frames after the fourth codon and the replacement with a PGK-neo cassette for the genomic sequences responsible for DNA binding and dimerization. (J:64193)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	39 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying E2f4^tm1Lees

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any E2f4 Mutation: 21 strains or lines available

References

• Original: J:64193 Humbert PO, et al., E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell. 2000 Aug;6(2):281-91
• All: 12 reference(s)