Chrna4^tm1Dra
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1Dra
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, John Drago
• MGI ID: MGI:1888964
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1Dra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64208
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin gene was inserted into the fifth exon. (J:64208)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 44 strains or lines available

References

• Original: J:64208 Ross SA, et al., Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J Neurosci. 2000 Sep 1;20(17):6431-41
• All: 11 reference(s)