Camk4^tm1Tch
Targeted Allele Detail

Summary

• Symbol: Camk4^tm1Tch
• Name: calcium/calmodulin-dependent protein kinase IV; targeted mutation 1, Talal A Chatila
• MGI ID: MGI:1888972
• Synonyms: Camk4^-, CaMKIV/Gr KO
• Gene: Camk4 Location: Chr18:33067984-33324281 bp, + strand Genetic Position: Chr18, 18.15 cM
• Alliance: Camk4^tm1Tch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64210
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The replacement of the third exon, which encodes the ATP binding site in the catalytic domain of the kinase, with a neomycin resistance gene rendered the enzyme catalytically inactive and prone to degradation. (J:64210)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Camk4 Mutation: 39 strains or lines available

References

• Original: J:64210 Ho N, et al., Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice. J Neurosci. 2000 Sep 1;20(17):6459-72
• All: 19 reference(s)