Ackr1^tm1Scp
Targeted Allele Detail

Summary

• Symbol: Ackr1^tm1Scp
• Name: atypical chemokine receptor 1 (Duffy blood group); targeted mutation 1, Stephen C Peiper
• MGI ID: MGI:1888977
• Synonyms: DARC-
• Gene: Ackr1 Location: Chr1:173159457-173161079 bp, - strand Genetic Position: Chr1, 80.33 cM
• Alliance: Ackr1^tm1Scp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64222
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequences corresponding to part of intron 1 and 90 bp of intron 2 were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that a nonfunctional message is produced from this allele in total RNA derived from spleen. Binding assays demonstrated a lack of functional protein in homozygous mice. (J:64222)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ackr1 Mutation: 24 strains or lines available

References

• Original: J:64222 Dawson TC, et al., Exaggerated response to endotoxin in mice lacking the duffy antigen/receptor for chemokines (DARC). Blood. 2000 Sep 1;96(5):1681-4
• All: 19 reference(s)