Lepr^{Tg(Mth11)1Aig}
Transgenic Allele Detail

Summary

• Symbol: Lepr^{Tg(Mth11)1Aig}
• Name: leptin receptor; transgene insertion 1, Bernhard Aigner
• MGI ID: MGI:1888983
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^{Tg(Mth11)1Aig} page

Transgene origin

• Strain of Origin: Him:OF1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Intragenic deletion
• Mutation details: The mutation was caused by insertion of a transgene. The construct contained 2.3 kb of the rabbit smooth muscle myosin heavy chain promoter region. The deletion extends from intron 17 into the 3' region of the gene. (J:61119)
• Inheritance: Not Specified

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

Notes

Authors report variations in the obesity and diabetes phenotypes with the outbred mice (Him:Of1).

References

• Original: J:61119 Reichart U, et al., Contrasting obesity phenotypes uncovered by partial leptin receptor gene deletion in transgenic mice. Biochem Biophys Res Commun. 2000 Mar 16;269(2):502-7
• All: 1 reference(s)