Gcm2^tm1Kry
Targeted Allele Detail

Summary

• Symbol: Gcm2^tm1Kry
• Name: glial cells missing homolog 2; targeted mutation 1, Gerard Karsenty
• MGI ID: MGI:1889069
• Synonyms: Gcm2^m1
• Gene: Gcm2 Location: Chr13:41254903-41264511 bp, - strand Genetic Position: Chr13, 20.31 cM
• Alliance: Gcm2^tm1Kry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63291
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced all four exons of the gene. RT-PCR did not amplify a product from the neck region of homozygous mutant mice. (J:63291)

Disease models

Expression

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcm2 Mutation: 34 strains or lines available

References

• Original: J:63291 Gunther T, et al., Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature. 2000 Jul 13;406(6792):199-203
• All: 11 reference(s)