Mtor^flat
Chemically induced Allele Detail

Summary

• Symbol: Mtor^flat
• Name: mechanistic target of rapamycin kinase; flat-top
• MGI ID: MGI:1889297
• Gene: Mtor Location: Chr4:148533068-148642140 bp, + strand Genetic Position: Chr4, 78.76 cM, cytoband E1
• Alliance: Mtor^flat page

Mutation origin

• Strain of Origin: BTBR T⁺ Itpr3^tf/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to A transversion in intron 7 alters splicing of the RNA and is predicted to produce two altered proteins a 385 amino acid N-terminal fragment and a full length protein with a 3 amino acid insertion. Only the full length protein with insertion is found. The mutant protein has decreased activity. (J:94381)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtor Mutation: 115 strains or lines available

References

• Original: J:53291 Hentges K, et al., The flat-top gene is required for the expansion and regionalization of the telencephalic primordium. Development. 1999 Apr;126(8):1601-9
• All: 2 reference(s)