Bey
Allele Detail

Summary

• Symbol: Bey
• Name: bulgy-eye
• MGI ID: MGI:1889298
• Gene: Bey Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Bey page

Mutation origin

• Strain of Origin: 129S/SvEv-Oca2⁺ Tyr⁺

Mutation description

• Allele Type: Not Applicable
• Mutation: Insertion
• Mutation details: This mutation was induced by retroviral mutagenesis using an 8.0 kb myeloproliferative sarcoma retrovirus MPSV-mos-neo in mouse embryonic stem cells; an additional 154 bp of unique sequence also integrated at the locus during mutagenesis. The insertion site was identified as the intergenic region between Fgf3 and Fgf4. The retrovirus landed in the opposite transcriptional orientation to both genes and is approximately 10 kb downstream of Fgf3 and 5 kb upstream of Fgf4. Ectopic expression of both genes was up-regulated in the cranial suture region in mutant mice. (J:47965)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bey Mutation: 0 strains or lines available

References

• Original: J:47965 Carlton MB, et al., Crouzon-like craniofacial dysmorphology in the mouse is caused by an insertional mutation at the Fgf3/Fgf4 locus. Dev Dyn. 1998 Jun;212(2):242-9
• All: 1 reference(s)