awg^{Tg(GBts1env)832Pkw}
Transgenic Allele Detail

Summary

• Symbol: awg^{Tg(GBts1env)832Pkw}
• Name: abnormal wobbly gait; transgene insertion 832, Paul Wong
• MGI ID: MGI:1889309
• Synonyms: abnormal wobbly gait, EY832, TgN832Pkw, TgN(GBts1env)832Pkw
• Gene: awg Location: unknown Genetic Position: Chr19, Syntenic
• Alliance: awg^{Tg(GBts1env)832Pkw} page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: In this transgenic line, a construct designed to express the viral envelope protein of a variant of the Moloney murine leukemia virus under the control of a human granzyme B promoter inserted randomly into an unidentified gene. Seven to eight copies of the transgene integrated in a head to tail orientation, and expression of the transgenic construct was restricted to the thymus in this line. No abnormalities were observed in other transgenic lines generated from the same construct, and hemizygous mice appear healthy, confirming that the mutant phenotype is a result of the construct integration event in this line.
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any awg Mutation: 0 strains or lines available

References

• Original: J:44593 Yu YE, et al., Loss of spermatogenic function after puberty in transgenic males harboring an unbalanced product of the reciprocal translocation T(3;10). Mouse Genome. 1996;94:695-7
• All: 2 reference(s)