Scrib^Crc
Spontaneous Allele Detail

Summary

• Symbol: Scrib^Crc
• Name: scribbled planar cell polarity; circletail
• MGI ID: MGI:1889322
• Synonyms: Crc
• Gene: Scrib Location: Chr15:75919011-75941633 bp, - strand Genetic Position: Chr15, 35.29 cM
• Alliance: Scrib^Crc page

Mutation origin

• Strain of Origin: (NMRI x C57BL/6J)F2

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Insertion
• Mutation details: A spontaneous mouse mutant that arose in a line carrying a tyrosinase minigene; however, the circletail mutation segregated independently of the transgene. Sequence analysis demonstrated that the coding region contained a single base insertion at codon 947, nucleotide 3182-3 compared with wild-type DNA. The nucleotide insertion is unique to the mutant, and is absent from 16 other mouse strains, including the parental strains on which mutation arose and other unrelated strains. The insertion is predicted to cause a frame shift resulting in a premature termination codon and truncation of the protein to 971 amino acids. Western blot analysis indicates complete absence of the full-length protein in homozygotes and no evidence for a truncated, 100-120 kDa isoform is detected. (J:81365, J:216413)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	53 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Scrib Mutation: 54 strains or lines available

References

• Original: J:62635 Rachel RA, et al., Retinal axon misrouting at the optic chiasm in mice with neural tube closure defects. Genesis. 2000 May;27(1):32-47
• All: 21 reference(s)