Large1^{enr-Tg(MbpReg)36Pop}
Transgenic Allele Detail

Summary

• Symbol: Large1^{enr-Tg(MbpReg)36Pop}
• Name: LARGE xylosyl- and glucuronyltransferase 1; enervated
• MGI ID: MGI:1889325
• Synonyms: BPFD #36, enr^Tg36Pop, Tg(Mbp)36Pop, TgN.BPFD #36
• Gene: Large1 Location: Chr8:73541227-74080164 bp, - strand Genetic Position: Chr8, 35.08 cM, cytoband C1
• Alliance: Large1^{enr-Tg(MbpReg)36Pop} page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: A transgene insertion 160kb downstream of the 3' end of the Large gene results in a severe reduction in the expression of Large mRNA. Expression of six other genes in the immediate vicinity of the transgene insertion was unaltered. Furthermore, noncomplementation tests between enr mutant mice and Large^myd mice demonstrated that these mutations are allelic. (J:96939)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Large1 Mutation: 123 strains or lines available

References

• Original: J:16281 Kelly D, et al., Autosomal recessive neuromuscular disorder in a transgenic line of mice. J Neurosci. 1994 Jan;14(1):198-207
• All: 3 reference(s)