Ppard^tm1Jps
Targeted Allele Detail

Summary

• Symbol: Ppard^tm1Jps
• Name: peroxisome proliferator activator receptor delta; targeted mutation 1, Jeffrey M Peters
• MGI ID: MGI:1889516
• Synonyms: PPARbeta^-, Pparbeta/delta-null
• Gene: Ppard Location: Chr17:28451715-28520446 bp, + strand Genetic Position: Chr17, 14.64 cM
• Alliance: Ppard^tm1Jps page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63040
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The last exon of this gene was disrupted by insertion of a neomycin resistance cassette via homologous recombination. Mutant transcript was detected in adipose, brain, and skin tissue from homozygous mutant animals by Northern blot analysis, but protein product was not detect in hepatic nuclear extract by Western blot analysis. (J:63040)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ppard^tm1Jps

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppard Mutation: 68 strains or lines available

References

• Original: J:63040 Peters JM, et al., Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol Cell Biol. 2000 Jul;20(14):5119-28
• All: 37 reference(s)