Kl^kl
Transgenic Allele Detail

Summary

• Symbol: Kl^kl
• Name: klotho
• MGI ID: MGI:1889570
• Synonyms: alpha-kl^-, kl, Kl^-, klotho^hm, Kl^Tg(SLC9A1)
• Gene: Kl Location: Chr5:150876072-150917282 bp, + strand Genetic Position: Chr5, 89.77 cM, cytoband G3
• Alliance: Kl^kl page

Transgene origin

• Strain of Origin: C57BL/6J and C3H/HeJ

Transgene description

• Transgene Type: Transgenic
• Mutation: Intergenic deletion
• Mutation details: This allele was discovered after mating and screening mice that did not express an exogenous transgene (rabbit type-I sodium-proton exchanger) in other work. One offspring from these matings showed an interesting phenotype, and the mutant was named klotho. It was determined that insertion of the unrelated, exogenous transgene had caused an 8 kb deletion in the 5' upstream region of the Kl locus in the mutant animal. (J:44109)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	45 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kl Mutation: 53 strains or lines available

References

• Original: J:44109 Kuro-o M, et al., Mutation of the mouse klotho gene leads to a syndrome resembling ageing [see comments]. Nature. 1997 Nov 6;390(6655):45-51
• All: 165 reference(s)