Nrg3^ska
Spontaneous Allele Detail

Summary

• Symbol: Nrg3^ska
• Name: neuregulin 3; scaramanga
• MGI ID: MGI:1889610
• Synonyms: ska
• Gene: Nrg3 Location: Chr14:38090909-39195045 bp, - strand Genetic Position: Chr14, 22.18 cM, cytoband B
• Alliance: Nrg3^ska page

Mammary gland abnormalities in Nrg3^ska/Nrg3^ska mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Duplication
• Mutation details: This allele maps to an interval between the microsatellite markers D14Mit14 and D14Mit80 located at 10.0 cM and 13.5 cM. The mutation identified is a microsatellite repeat within intron 7 of the gene. This simple sequence repeat (SSR) was found to completely cosegregate with the ska phenotype. (J:100495)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 21 strains available Cell Lines: 0 lines available
• Carrying any Nrg3 Mutation: 54 strains or lines available

References

• Original: J:60708 Howard BA, et al., The characterization of a mouse mutant that displays abnormal mammary gland development. Mamm Genome. 2000 Mar;11(3):234-7
• All: 5 reference(s)