Ssq
Transgenic Allele Detail

Summary

• Symbol: Ssq
• Name: sasquatch
• MGI ID: MGI:1889614
• Gene: Ssq Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Ssq page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic
• Mutation: Insertion
• Mutation details: The Ssq mutation was generated by random transgene insertional mutagenesis using a reporter construct. The reporter construct consisted of Hoxb1 with a 110bp deletion spanning its initiation codon and fused to a human placental alkaline phosphatase sequence. Two integration sites occurred on proximal chromosome 5. The most proximal integration site was in intron 5 of Lmbr1 about 800 kb from Shh and segregates with the homozygous phenotype. About 20kb of intron 5 sequence were duplicated during the course of transgene insertion with the transgene residing between the duplicated segments. Expression level of full length Lmbr1 is reduced to 10-30% of normal levels and ectopic expression of Shh is observed. (J:52453, J:82883, J:150634)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssq Mutation: 0 strains or lines available

References

• Original: J:150634 Itasaki N, et al., Reprogramming Hox expression in the vertebrate hindbrain: influence of paraxial mesoderm and rhombomere transposition. Neuron. 1996 Mar;16(3):487-500
• All: 3 reference(s)