Slc40a1^Pcm
Radiation induced Allele Detail

Summary

• Symbol: Slc40a1^Pcm
• Name: solute carrier family 40 (iron-regulated transporter), member 1; polycythaemia
• MGI ID: MGI:1889622
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^Pcm page

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: A 58 bp microdeletion in the Fpn1 promoter region alters transcription start sites and eliminates the iron responsive element (IRE) in the 5' untranslated region, resulting in increased duodenal and hepatic Fpn1 protein levels during early postnatal development. (J:89185, J:110585)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 54 strains or lines available

References

• Original: J:30568 Cattanach BM, A new a^t mutation/ A dominant polycythaemia. Mouse Genome. 1995;93(4):1026-1029
• All: 5 reference(s)