Vegfa^tm1.1Nagy
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm1.1Nagy
• Name: vascular endothelial growth factor A; targeted mutation 1.1, Andras Nagy
• MGI ID: MGI:1889787
• Synonyms: VEGF-A^hyper, Vegf^hi, Vegf-IRES-lacZ, VEGF^LacZ, VEGF^lacZ-KI, VEGF-LacZ-KI-delta-neo
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm1.1Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:56939
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele is a derivative of Vegf^tm1Nagy where the PGK-neomycin resistance cassette has been deleted via a Cre/loxP recombination event. The allele expresses a bicistronic message encoding VEGF and LacZ proteins. (J:56939)

Expression

In Mice Carrying this Mutation:	119 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 38 strains or lines available

Notes

The LacZ staining from this allele is indistinguishable from Vegf^tm1Nagy.

References

• Original: J:56939 Miquerol L, et al., Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol. 1999 Aug 15;212(2):307-22
• All: 35 reference(s)