Map7^mshi
Spontaneous Allele Detail

Summary

• Symbol: Map7^mshi
• Name: microtubule-associated protein 7; male sterility and histoincompatibility
• MGI ID: MGI:1889849
• Gene: Map7 Location: Chr10:20024666-20157336 bp, + strand Genetic Position: Chr10, 9.75 cM
• Alliance: Map7^mshi page

Map7^mshi/Map7^mshi mice display abnormal seminiferous epithelium morphology

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/cBy

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: A large 13,080 bp deletion begins at nucleotide 1616 in intron 10 and extends to nucleotide 1959 in the 3' downstream sequence beyond exon 18. Exon 10 is then spliced to a cryptic "exon 11M" 4213 bp downstream of the deletion breakpoint. Exon 11M is, in turn, spliced to a second cryptic "exon 12M" located 830 bp downstream of exon 11M. The resulting 1724 nucleotide transcript is predicted to code for a 457 amino acid mutant protein. (J:148349)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	8 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Map7 Mutation: 240 strains or lines available

References

• Original: J:37165 Ward-Bailey PF, et al., A new mouse mutation causing male sterility and histoincompatibility. Mamm Genome. 1996 Nov;7(11):793-7
• All: 5 reference(s)