Tg(TCF3/HLF)1Mlc
Transgene Detail

Summary

• Symbol: Tg(TCF3/HLF)1Mlc
• Name: transgene insertion 1, Michael L Cleary
• MGI ID: MGI:1889853
• Synonyms: E2A-HLF
• Transgene: Tg(TCF3/HLF)1Mlc Location: unknown
• Alliance: Tg(TCF3/HLF)1Mlc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TCF3/HLF)1Mlc expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLF (3131)

  Hlf	(MGI:96108)

  Transgene codes for a fusion protein of TCF3 and HLF.

  human

  TCF3 (6929)

  Tcf3	(MGI:98510)

  Transgene codes for a fusion protein of TCF3 and HLF.

• Mutation details: The transgene consists of the fusion product between the human genes TCF3 and HLF, as cloned from a translocation t(17;19) event. It was positioned downstream the SV40 promoter and an IGH enhancer, which drives expression in both B and T lymphoid lineages. (J:55022)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55022 Smith KS, et al., Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. Mol Cell Biol. 1999 Jun;19(6):4443-51
• All: 1 reference(s)