Ctsl^nkt
Radiation induced Allele Detail

Summary

• Symbol: Ctsl^nkt
• Name: cathepsin L; nackt
• MGI ID: MGI:1889860
• Synonyms: nkt
• Gene: Ctsl Location: Chr13:64509704-64518586 bp, - strand Genetic Position: Chr13, 33.26 cM
• Alliance: Ctsl^nkt page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: Arose spontaneously in a stock derived from an irradiated founder in Germany in 1981. Molecular analysis of the coding region in nackt mice revealed a 118 bp deletion involving the end of exon 6 and almost all of exon 7. Western analysis of skin from homozygous mutant mice indicated that no stable protein is produced. (J:69924, J:108004)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ctsl Mutation: 32 strains or lines available

References

• Original: J:54856 Benavides F, et al., Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency. Immunogenetics. 1999 May;49(5):413-9
• All: 10 reference(s)