Ndst1^tm1Hgx
Targeted Allele Detail

Summary

• Symbol: Ndst1^tm1Hgx
• Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Gengxi Hu
• MGI ID: MGI:1889939
• Synonyms: NDST-1(-)
• Gene: Ndst1 Location: Chr18:60817566-60881722 bp, - strand Genetic Position: Chr18, 34.38 cM, cytoband D2
• Alliance: Ndst1^tm1Hgx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60280
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A PGK-neo cassette was inserted into exon 1 to generate the null mice. (J:60280)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndst1 Mutation: 47 strains or lines available

References

• Original: J:60280 Fan G, et al., Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice. FEBS Lett. 2000 Feb 4;467(1):7-11
• All: 3 reference(s)