Lhx2^tm1Dra
Targeted Allele Detail

Summary

• Symbol: Lhx2^tm1Dra
• Name: LIM homeobox protein 2; targeted mutation 1, John Drago
• MGI ID: MGI:1890208
• Synonyms: Lh2^sKO, Lhx -
• Gene: Lhx2 Location: Chr2:38229293-38259745 bp, + strand Genetic Position: Chr2, 24.31 cM, cytoband B
• Alliance: Lhx2^tm1Dra page

Hair follicles of tamoxifen-treated Lhx2^tm1.1Lcar/Lhx2^tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaft

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64676
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2 and 3, which encode the LIM domains, the domain linking these two, and the homeodomains of the protein. (J:64676)

Expression

In Mice Carrying this Mutation:	341 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx2 Mutation: 12 strains or lines available

References

• Original: J:64676 Porter FD, et al., Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. 1997 Aug;124(15):2935-44
• All: 40 reference(s)