Tg(BCL2)1Tsk
Transgene Detail

Summary

• Symbol: Tg(BCL2)1Tsk
• Name: transgene insertion 1, Thomas S Kupper
• MGI ID: MGI:1891501
• Synonyms: K14/Bcl-2
• Transgene: Tg(BCL2)1Tsk Location: unknown
• Alliance: Tg(BCL2)1Tsk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(BCL2)1Tsk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BCL2 (596)

  Bcl2	(MGI:88138)

• Mutation details: Transgenic mice overexpress human BCL2 gene in basal epidermis and root sheath. The transgene is driven by human keratin 14 promoter. (J:64948)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two lines established, line 1 and line 7. Lines not distinguished by phenotype in publication.

References

• Original: J:64948 Muller-Rover S, et al., Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia. Am J Pathol. 2000 Apr;156(4):1395-405
• All: 2 reference(s)