Jph2^tm1Hta
Targeted Allele Detail

Summary

• Symbol: Jph2^tm1Hta
• Name: junctophilin 2; targeted mutation 1, Hiroshi Takeshima
• MGI ID: MGI:1891502
• Synonyms: JP-2^-
• Gene: Jph2 Location: Chr2:163178162-163239913 bp, - strand Genetic Position: Chr2, 84.22 cM, cytoband H3
• Alliance: Jph2^tm1Hta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63879
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The protein-coding sequences of the first exon and part of the first intron were replaced with a neomycin cassette. Immunoblot analysis on total protein from embryonic heart demonstrated that no detectable protein was expressed from this allele. (J:63879)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jph2 Mutation: 22 strains or lines available

References

• Original: J:63879 Takeshima H, et al., Junctophilins: a novel family of junctional membrane complex proteins. Mol Cell. 2000 Jul;6(1):11-22
• All: 1 reference(s)