Bdnf^tm1Tbn
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1Tbn
• Name: brain derived neurotrophic factor; targeted mutation 1, Tobias Bonhoeffer
• MGI ID: MGI:1891516
• Synonyms: BDNF(-)
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1Tbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64962
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was used to replace a 560-bp fragment of the gene, which contains most of the coding sequence. (J:64962)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:64962 Korte M, et al., Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8856-60
• All: 29 reference(s)