Tg(CTNNB1)1Efu
Transgene Detail

Summary

• Symbol: Tg(CTNNB1)1Efu
• Name: transgene insertion 1, Elaine Fuchs
• MGI ID: MGI:1891520
• Synonyms: deltaN87Betacat
• Transgene: Tg(CTNNB1)1Efu Location: unknown
• Alliance: Tg(CTNNB1)1Efu page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CTNNB1)1Efu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CTNNB1 (1499)

  Ctnnb1

  (MGI:88276)

  Expresses a truncated human catenin beta 1 gene

• Mutation details: The keratin 14 promoter drives the expression of a truncated human catenin beta 1 gene. The gene encodes a polypeptide lacking the N-terminal 87 amino acyl residues of the full length protein. Expression targeted to dividing cells of the basal epidermis and the outer root sheath of hair follicles. (J:51296)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CTNNB1)1Efu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two transgenic mouse lines established; not distinguished in paper.

References

• Original: J:51296 Gat U, et al., De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell. 1998 Nov 25;95(5):605-14
• All: 4 reference(s)