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Ets2tm1Rgo
Targeted Allele Detail
Summary
Symbol: Ets2tm1Rgo
Name: E26 avian leukemia oncogene 2, 3' domain; targeted mutation 1, Robert G Oshima
MGI ID: MGI:1891557
Synonyms: Ets2db, ets2db1
Gene: Ets2  Location: Chr16:95503274-95522093 bp, + strand  Genetic Position: Chr16, 56.64 cM, cytoband C3-qter
Alliance: Ets2tm1Rgo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47620
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    All or part of three exons encoding the DNA binding domain were replaced with pMC1NeoA. (J:43739)
Inheritance:    Recessive
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Allelic CompositionGenetic BackgroundCell Line(s)
either: (involves: 129S2/SvPas * 129/Sv) or (involves: 129S2/SvPas * Black Swiss)
 
involves: FVB/N
 
involves: 129S2/SvPas * FVB/N
 
involves: 129S2/SvPas * FVB/N
 
involves: 129S2/SvPas * FVB/N
 
involves: 129S2/SvPas * Black Swiss * FVB/N
 
Phenotypes:
Affected Systems
show or hide all annotated terms
           
cardiovascular system
absent vitelline blood vessels
embryo
decreased embryo size
abnormal extraembryonic tissue morphology
absent vitelline blood vessels
abnormal ectoplacental cone morphology
abnormal trophoblast layer morphology
abnormal trophoblast giant cell morphology
endocrine/exocrine glands
N
endocrine/exocrine gland phenotype
N
decreased mammary gland tumor incidence
increased mammary gland tumor incidence
growth/size/body
decreased embryo size
integument
decreased mammary gland tumor incidence
increased mammary gland tumor incidence
increased curvature of auchene hairs
increased curvature of awl hairs
waved hair
increased curvature of guard hairs
increased curvature of zigzag hairs
abnormal hair follicle orientation
curly vibrissae
mortality/aging
embryonic lethality during organogenesis, complete penetrance
embryonic lethality between somite formation and embryo turning, complete penetrance
neoplasm
decreased mammary gland tumor incidence
increased mammary gland tumor incidence
abnormal tumor morphology
decreased tumor growth/size
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ets2tm1Rgo
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ets2 Mutation:  39 strains or lines available
References
Original:  J:47620 Yamamoto H, et al., Defective trophoblast function in mice with a targeted mutation of Ets2. Genes Dev. 1998 May 1;12(9):1315-26
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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