Myf6^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Myf6^tm1Eno
• Name: myogenic factor 6; targeted mutation 1, Eric N Olson
• MGI ID: MGI:1913092
• Synonyms: Mrf4-
• Gene: Myf6 Location: Chr10:107328709-107330584 bp, - strand Genetic Position: Chr10, 55.96 cM
• Alliance: Myf6^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26105
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette was inserted into the Myf6 gene such that all sequences 3' of codon 69 are removed. These deleted sequences encode the bHLH region of the 1st exon and the entire carboxyl terminus. Myf5 expression does not appear to be altered in this allele. (J:26105)

Expression

In Mice Carrying this Mutation:	108 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myf6 Mutation: 19 strains or lines available

Notes

Studies have shown that Myf6 may regulate Myf5 expression by a cis-acting mechanism and that the skeletal abnormalities seen in Myf6 homozygotes may result from a decrease or lack of Myf5 expression. This allele (Myf6^tm1Eno) does not display reduced expression of Myf5 and thus may exhibit the true Myf6 null phenotype unlike other Myf6 alleles that may have phenotypes resulting from the reduction or lack of Myf5 (J:26105, J:42453).

References

• Original: J:26105 Zhang W, et al., Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies. Genes Dev. 1995 Jun 1;9(11):1388-99
• All: 10 reference(s)