Ndst2^tm1Rls
Targeted Allele Detail

Summary

• Symbol: Ndst2^tm1Rls
• Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2; targeted mutation 1, Richard L Stevens
• MGI ID: MGI:1913286
• Synonyms: NDST-2-null
• Gene: Ndst2 Location: Chr14:20773798-20784630 bp, - strand Genetic Position: Chr14, 11.53 cM, cytoband B
• Alliance: Ndst2^tm1Rls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57120
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of amino acids 539 to 580 with a neomycin resistance gene and the introduction of a premature stop codon after residue 538. (J:57120)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndst2 Mutation: 27 strains or lines available

References

• Original: J:57120 Humphries DE, et al., Heparin is essential for the storage of specific granule proteases in mast cells [see comments]. Nature. 1999 Aug 19;400(6746):769-72
• All: 4 reference(s)