E2f5^tm1Dli
Targeted Allele Detail

Summary

• Symbol: E2f5^tm1Dli
• Name: E2F transcription factor 5; targeted mutation 1, David M Livingston
• MGI ID: MGI:1926192
• Synonyms: E2F-5^-
• Gene: E2f5 Location: Chr3:14643701-14671369 bp, + strand Genetic Position: Chr3, 3.1 cM
• Alliance: E2f5^tm1Dli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47283
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The two exons encoding the carboxy-terminal half of the DNA-binding and the leucine zipper domains were replaced with a neomycin resistance gene. (J:47283)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any E2f5 Mutation: 13 strains or lines available

References

• Original: J:47283 Lindeman GJ, et al., A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev. 1998 Apr 15;12(8):1092-8
• All: 4 reference(s)