Chrna4^tm1Jpc
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1Jpc
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, Jean-Pierre Changeux
• MGI ID: MGI:1926251
• Synonyms: alpha4 ^-
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1Jpc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' portion of exon 5 (encoding three of the four putative transmembrane spanning domains and the acetylcholine binding site) and 400 base pairs of the upstream intron sequence were replaced with a neomycin resistance gene. (J:54505)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 44 strains or lines available

References

• Original: J:54505 Marubio LM, et al., Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature. 1999 Apr 29;398(6730):805-10
• All: 10 reference(s)