Chrnb2^tm1Jpc
Targeted Allele Detail

Summary

• Symbol: Chrnb2^tm1Jpc
• Name: cholinergic receptor nicotinic beta 2 subunit; targeted mutation 1, Jean-Pierre Changeux
• MGI ID: MGI:1926253
• Synonyms: beta2-, beta2-KO
• Gene: Chrnb2 Location: Chr3:89660755-89671939 bp, - strand Genetic Position: Chr3, 39.19 cM
• Alliance: Chrnb2^tm1Jpc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23256
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The start codon and the rest of exon 1 was replaced by a lacZ reporter gene and a neomycin resistance gene. (J:23256)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrnb2 Mutation: 32 strains or lines available

References

• Original: J:23256 Picciotto MR, et al., Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 1995 Mar 2;374(6517):65-7
• All: 87 reference(s)