Tcf7^tm2Cle
Targeted Allele Detail

Summary

• Symbol: Tcf7^tm2Cle
• Name: transcription factor 7, T cell specific; targeted mutation 2, Hans Clevers
• MGI ID: MGI:1926299
• Synonyms: Tcf^deltaV
• Gene: Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
• Alliance: Tcf7^tm2Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23255
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 350-bp fragment encoding part of intron IV and exon V was replaced with a neomycin cassette. A novel mRNA was detected in homozgyote thymocytes at 15% of the wild-type mRNA level. This mutant mRNA contains a splice variant of exon 4 to exon 6. This allele is considered a hypomorph. (J:23255)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7 Mutation: 26 strains or lines available

References

• Original: J:23255 Verbeek S, et al., An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature. 1995 Mar 2;374(6517):70-4
• All: 4 reference(s)