Atm^tm1Bal
Targeted Allele Detail

Summary

• Symbol: Atm^tm1Bal
• Name: ataxia telangiectasia mutated; targeted mutation 1, David Baltimore
• MGI ID: MGI:1926343
• Synonyms: ATM-
• Gene: Atm Location: Chr9:53350449-53448040 bp, - strand Genetic Position: Chr9, 29.12 cM, cytoband C-D
• Alliance: Atm^tm1Bal page

Electron micrographs of wild type and Atm^tm1Bal/Atm^tm1Bal Purkinje neurons

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42324
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of an exon encoding the kinase-conserved sequence of Atm and the following 3' exon was replaced with a PGK-neomycin cassette. (J:42324)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Atm^tm1Bal

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atm Mutation: 170 strains or lines available

References

• Original: J:42324 Xu Y, et al., Dual roles of ATM in the cellular response to radiation and in cell growth control [see comments]. Genes Dev. 1996 Oct 1;10(19):2401-10
• All: 28 reference(s)