Tcf7l2^tm1Cle
Targeted Allele Detail

Summary

• Symbol: Tcf7l2^tm1Cle
• Name: transcription factor 7 like 2, T cell specific, HMG box; targeted mutation 1, Hans Clevers
• MGI ID: MGI:1926344
• Synonyms: Tcf-4-, Tcf4-, Tcf7l2-
• Gene: Tcf7l2 Location: Chr19:55730252-55922086 bp, + strand Genetic Position: Chr19, 51.59 cM
• Alliance: Tcf7l2^tm1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48968
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Gene disruption caused by insertion of a PGK-hygromycin selection cassette into the exon containing coding sequences for the N-terminal region of the DNA-binding HMG box. (J:48968)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	60 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf7l2 Mutation: 58 strains or lines available

References

• Original: J:48968 Korinek V, et al., Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet. 1998 Aug;19(4):379-83
• All: 17 reference(s)