Tg(EGFR)3Jlj
Transgene Detail
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Symbol: |
Tg(EGFR)3Jlj |
Name: |
transgene insertion 3, Jose Luis Jorcano |
MGI ID: |
MGI:1926353 |
Synonyms: |
K5-HERCD-533, T3 |
Transgene: |
Tg(EGFR)3Jlj Location: unknown
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Alliance: |
Tg(EGFR)3Jlj page
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Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(EGFR)3Jlj expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
EGFR (1956) |
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Expresses a truncated human EGFR, lacking most of its cytoplasmic domain (HERCD-
533) |
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Tg(EGFR)3Jlj expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
cattle |
KRT5 (281268) |
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Mutation details: Overexpression of a dominant negative, truncated form of human EGFR in basal cell compartment of stratified squamous epithelia driven by the bovine keratin K5 promoter (KRT2-5).
(J:65031)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:65031 Murillas R, et al., Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J. 1995 Nov 1;14(21):5216-23 |
All: |
1 reference(s) |
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