Tg(EGFR)4Jlj
Transgene Detail

Summary

• Symbol: Tg(EGFR)4Jlj
• Name: transgene insertion 4, Jose Luis Jorcano
• MGI ID: MGI:1926355
• Synonyms: K5-HERCD-533, T4
• Transgene: Tg(EGFR)4Jlj Location: unknown
• Alliance: Tg(EGFR)4Jlj page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(EGFR)4Jlj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EGFR (1956)

  Egfr	(MGI:95294)

  Expresses a truncated human EGFR, lacking most of its cytoplasmic domain (HERCD- 533)

• Tg(EGFR)4Jlj expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: Overexpression of a dominant negative, truncated form of human EGFR in basal cell compartment of stratified squamous epithelia driven by the bovine keratin K5 promoter (KRT2-5). (J:65031)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:65031 Murillas R, et al., Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure. EMBO J. 1995 Nov 1;14(21):5216-23
• All: 1 reference(s)