Foxn1^tm1Tbo
Targeted Allele Detail

Summary

• Symbol: Foxn1^tm1Tbo
• Name: forkhead box N1; targeted mutation 1, Thomas Boehm
• MGI ID: MGI:1926361
• Synonyms: nude^-, WHN^-, Whn^beta-gal
• Gene: Foxn1 Location: Chr11:78248403-78277384 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Foxn1^tm1Tbo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33796
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an IRES-beta-galactosidase-neomycin cassette into the third exon results in disruption of the gene. This mutation was made close to the site of the spontaneous mutation in Foxn1^nu. (J:33796)

Disease models

Expression

In Mice Carrying this Mutation:	77 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxn1 Mutation: 106 strains or lines available

References

• Original: J:33796 Nehls M, et al., Two genetically separable steps in the differentiation of thymic epithelium. Science. 1996 May 10;272(5263):886-9
• All: 14 reference(s)