Cdx2^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Cdx2^tm1Mmt
• Name: caudal type homeobox 2; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:1926374
• Synonyms: Cdx2-, Cdx2^Beta-gal
• Gene: Cdx2 Location: Chr5:147237710-147244059 bp, - strand Genetic Position: Chr5, 86.86 cM, cytoband G2-G3
• Alliance: Cdx2^tm1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47050
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The ATG translation initiation codon in exon 1 was deleted and replaced with a lacZ reporter gene and a neomycin selection cassette. (J:47050)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdx2^tm1Mmt

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdx2 Mutation: 22 strains or lines available

References

• Original: J:47050 Tamai Y, et al., Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res. 1999 Jun 15;59(12):2965-70
• All: 4 reference(s)