Tg(APOC1)3Lmh
Transgene Detail

Summary

• Symbol: Tg(APOC1)3Lmh
• Name: transgene insertion 3, Louis M Havekes
• MGI ID: MGI:1926380
• Synonyms: 11/3, APOC1
• Transgene: Tg(APOC1)3Lmh Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(APOC1)3Lmh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOC1)3Lmh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOC1 (341)

  Apoc1

  (MGI:88053)

• Mutation details: Overexpression of human apolipoprotein C gene (APOC1) in liver and skin. This is a low expresser line. Northern blot analysis showed that APOC1 mRNA expression is confined mainly to the liver, although low but significant levels or expression are found in other tissues. (J:65146)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Allele Notes: Low expressor strain.

References

• Original: J:65146 Jong MC, et al., In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway. J Clin Invest. 1996 Nov 15;98(10):2259-67
• All: 3 reference(s)