Msx2^tm1Rilm
Targeted Allele Detail

Summary

• Symbol: Msx2^tm1Rilm
• Name: msh homeobox 2; targeted mutation 1, Richard Maas
• MGI ID: MGI:1926381
• Synonyms: Msx2-
• Gene: Msx2 Location: Chr13:53620917-53626816 bp, - strand Genetic Position: Chr13, 27.84 cM
• Alliance: Msx2^tm1Rilm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61509
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Gene disruption caused by insertion of a pMC1-neo cassette into coding sequences located just 5' to the homeobox domain in exon 2. (J:61509)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	106 assay results
In Structures Affected by this Mutation:	37 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msx2 Mutation: 23 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Peters anomaly in homozygous mice (J:184697)

References

• Original: J:61509 Satokata I, et al., Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet. 2000 Apr;24(4):391-5
• All: 32 reference(s)