Gab1^tm1Thir
Targeted Allele Detail

Summary

• Symbol: Gab1^tm1Thir
• Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 1, Toshio Hirano
• MGI ID: MGI:1926435
• Synonyms: Gab1^-
• Gene: Gab1 Location: Chr8:81491067-81607148 bp, - strand Genetic Position: Chr8, 38.47 cM, cytoband C3
• Alliance: Gab1^tm1Thir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61790
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A cassette consisting of a splice acceptor site from the mouse En2 gene, an internal ribosomal entry site (IRES), and a beta-galactosidase-neomycin resistance gene fusion replaced 3.0 kb of sequence encoding a part of the pleckstrin homology domain. (J:61790)

Expression

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gab1 Mutation: 78 strains or lines available

References

• Original: J:61790 Itoh M, et al., Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol Cell Biol. 2000 May;20(10):3695-704
• All: 7 reference(s)