Tg(FGF7)11Efu
Transgene Detail

Summary

• Symbol: Tg(FGF7)11Efu
• Name: transgene insertion 11, Elaine Fuchs
• MGI ID: MGI:1926458
• Synonyms: K14-KGF, KGF-m11
• Transgene: Tg(FGF7)11Efu Location: unknown
• Alliance: Tg(FGF7)11Efu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(FGF7)11Efu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF7 (2252)

  Fgf7	(MGI:95521)

• Mutation details: Overexpression of the human FGF7 gene in basal cells of stratified squamous epithelia driven by the human K14 (KRT14) promoter. (J:65032)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder number 11 survived to adulthood and was fertile.

See Tg(FGF7)2Efu and Tg(FGF7)29Efu for variability in phenotypes using this construct.

References

• Original: J:65032 Guo L, et al., Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J. 1993 Mar;12(3):973-86
• All: 1 reference(s)