Tg(FGF7)29Efu
Transgene Detail

Summary

• Symbol: Tg(FGF7)29Efu
• Name: transgene insertion 29, Elaine Fuchs
• MGI ID: MGI:1926459
• Synonyms: K14-KGF, KGF-f29
• Transgene: Tg(FGF7)29Efu Location: unknown
• Alliance: Tg(FGF7)29Efu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(FGF7)29Efu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF7 (2252)

  Fgf7	(MGI:95521)

• Mutation details: Overexpression of the human FGF7 gene in basal cells of stratified squamous epithelia driven by the human K14 (KRT14) promoter. (J:65032)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder number 29 is representative of founders that survived to adulthood but are infertile. These founder numbers were designated 29, 72 and 86. Due to infertility, no mouse lines were established.

See Tg(FGF7)2Efu and Tg(FGF7)11Efu for variablilty in phenotypes using this construct.

References

• Original: J:65032 Guo L, et al., Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J. 1993 Mar;12(3):973-86
• All: 1 reference(s)