Tg(FGF7)2Efu
Transgene Detail

Summary

• Symbol: Tg(FGF7)2Efu
• Name: transgene insertion 2, Elaine Fuchs
• MGI ID: MGI:1926467
• Synonyms: K14-KGF, KGF-NB2
• Transgene: Tg(FGF7)2Efu Location: unknown
• Alliance: Tg(FGF7)2Efu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(FGF7)2Efu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGF7 (2252)

  Fgf7	(MGI:95521)

• Mutation details: Overexpression of the human FGF7 gene in basal cells of stratified squamous epithelia driven by the human K14 (KRT14) promoter. (J:65032)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder number 2 is representative of a number of founders that exhibit perinatal lethality at birth to postnatal day 1. These founder numbers were designated 2, 4, 5, 6, 7, 8, 9, 12, and 13. Due to lethality, no mouse lines were established.

See Tg(FGF7)11Efu and Tg(FGF7)29Efu for variability in phenotypes using this construct.

References

• Original: J:65032 Guo L, et al., Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. EMBO J. 1993 Mar;12(3):973-86
• All: 1 reference(s)