Tg(JUP)45Pac
Transgene Detail

Summary

• Symbol: Tg(JUP)45Pac
• Name: transgene insertion 45, Pamela Cowin
• MGI ID: MGI:1926474
• Synonyms: K14-deltaN80PG
• Transgene: Tg(JUP)45Pac Location: unknown
• Alliance: Tg(JUP)45Pac page

Transgene origin

• Strain of Origin: Swiss Webster

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(JUP)45Pac expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  JUP (3728)

  Jup	(MGI:96650)

• Mutation details: Overexpression of an N-terminal deleted form of human plakoglobin (JUP) in the basal layer of the interfollicular epidermis and the outer root sheath of hair follicles driven by the human keratin 14 (KRT14) promoter. 15 copies of the gene were inserted, as estimated by southern blot analysis. (J:61768)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:61768 Charpentier E, et al., Plakoglobin suppresses epithelial proliferation and hair growth in vivo. J Cell Biol. 2000 Apr 17;149(2):503-20
• All: 1 reference(s)