Tg(Il1a)1.1Tsk
Transgene Detail

Summary

• Symbol: Tg(Il1a)1.1Tsk
• Name: transgene insertion 1.1, Thomas Kupper
• MGI ID: MGI:1926481
• Synonyms: TgIL-1.1
• Transgene: Tg(Il1a)1.1Tsk Location: unknown
• Alliance: Tg(Il1a)1.1Tsk page

Microscopic changes in the skin of Tg(Il1a)1.1Tsk/Tg(Il1a)1.1Tsk mice.

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Il1a)1.1Tsk expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il1a (MGI:96542)

• Mutation details: Overexpression of mouse interleukin1 alpha (Il1a) in basal keratinocytes driven by the human keratin 14 (KRT14) promoter. Six copies of the gene were inserted, as estimated by southern blot analysis. (J:30162)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:30162 Groves RW, et al., Inflammatory skin disease in transgenic mice that express high levels of interleukin 1 alpha in basal epidermis. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11874-8
• All: 2 reference(s)